Barnaul, Barkaul, Russian Federation
This article continues a series of reviews about the structure and functions of milk fat globule membrane (MFGM) proteins in cow’s milk. This installment introduces publications on the biochemistry of fatty acid binding protein (FABP), which is a polypeptide component of MFGM. The article gives a brief history of its discovery, as well as profiles the proteins that bind hydrophobic ligands and describes the methods of FABP identification in MFGM preparations. Other aspects of FABP studies include: isoforms and modern nomenclature; amino acid sequence and reactions to post-translational modification; spatial organization; mechanisms for binding fatty acids to lipids; well-investigated and hypothesized physiological functions; the effect of haplotypes on milk fatty acids, yield, and protein content.
milk, milk fat globule membrane (MFGM) proteins, fatty acid binding protein, structure, function
1. Brandt, R. A. 13-kilodalton protein purified from milk fat globule membranes is closely related to a mammary-derived growth inhibitor / R. A. Brandt [et al.] // Biochemistry. 1988. V. 27. P. 1420-1425. https://www.doi.org/10.1021/bi00405a005
2. Böhmer, F.-D. Identification of a polypeptide growth inhibitor from bovine mammary gland. Sequence homology to fatty acid- and retinoid-binding proteins / F.-D. Böhmer [et al.] // The Journal of biological chemistry. 1987. V. 262. P. 15137-15143.
3. Böhmer, F.-D. Purification of a growth inhibitor for Ehrlich ascites mammary carcinoma cells from bovine mammary gland / F.-D. Böhmer [et al.] // Experimental cell research. 1984. Vol. 150(2). 466-476. https://doi.org/10.1016/0014-4827(84)90591-3
4. Bansal, M. P. Expression of fatty acid binding proteins in the developing mouse mammary gland / M. P. Bansal, D. Medina // Biochemical and biophysical research communications. 1993. Vol. 191(1). 61-69. https://doi.org/10.1006/bbrc.1993.1184
5. Specht, B. Mammary derived growth inhibitor is not a distinct protein but amix of heart-type and adipocytetype fatty acid-binding protein / B. Specht [et al.] // The Journal of biological chemistry. 1996. Vol. 271(33). 19943-19949. https://doi.org/10.1074/jbc.271.33.19943
6. Smathers, R. L. The human fatty acid-binding protein family: Evolutionary divergences and functions / R. L. Smathers, D. R. Petersen // Human genomics. 2011. Vol. 5(3). 170-191. https://doi.org/10.1186/1479-7364-5-3-170
7. Mather, I. H. A review and proposed nomenclature for major proteins of the milk-fat globule membrane / I. H. Mather // Journal of dairy science. 2000. Vol 83(2). 203-247. https://doi.org/10.3168/jds.S0022-0302(00)74870-3
8. UniProt KB - baza dannyh posledovatel'nostey belkov. Results or search "FABP" as a Protein family, Protein Name, or Gene Name [Elektronnyy resurs]. URL: https://www.uniprot.org/uniprotkb? (data obrascheniya: 13.09.2023).
9. Bionaz, M. ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation / M. Bionaz, J. J. Loor // The Journal of nutrition. 2008. Vol. 138(6), 1019-1024. https://doi.org/10.1093/jn/138.6.1019
10. Nafikov, R. A. Associations of polymorphisms in solute carrier family 27, isoform A6 (SLC27A6) and fatty acid-binding protein-3 and fatty acid-binding protein-4 (FABP3 and FABP4) with fatty acid composition of bovine milk / R. A. Nafikov [et al.] // Journal of dairy science. 2013. V. 96. P. 6007-6021. https://doi.org/10.3168/jds.2013-6703
11. UniProt KB - baza dannyh posledovatel'nostey belkov. P48035 FABP4_BOVIN - Fatty acid-binding protein, adipocyte Bos taurus (Bovine) Gene: FABP4, 132 amino acids [Elektronnyy resurs]. URL: https://www.uniprot.org/uniprotkb/P48035/entry (data obrascheniya: 15.09.2023).
12. Banaszak, L. Lipid-binding proteins: a family of fatty acid and retinoid transport proteins / L. Banaszak [et al.] // Advances in Protein Chemistry. 1994. V. 45. P. 89-151. https://doi.org/10.1016/S0065-3233(08)60639-7
13. Monaco, H. L. Crystal structure of the trigonal form of bovine beta-lactoglobulin and of its complex with retinol at 2.5 A resolution / H. L. Monaco [et al.] // Journal of molecular biology. 1987. V. 197. P. 695-706. https://doi.org/10.1016/0022-2836(87)90476-1
14. Xu, Z. The adipocyte lipid-binding protein at 1.6-A resolution. Crystal structures of the apoprotein and with bound saturated and unsaturated fatty acids / Z. Xu, D. A. Bernlohr, L. J. Banaszak // The Journal of biological chemistry. 1993. V. 268. P. 7874-7884.
15. Yang, Y. Members of the fatty acid binding protein family are differentiation factors for the mammary gland / Y. Yang [et al.] // J. Cell Biol. - 1994. - V. 127. - P. 1097-1109.
16. Handbook of Experimental Pharmacology. Vol. 95/II. Peptide Growth Factors and Their Receptors. Mammary-derived growth inhibitor / R. Grosse, P. Langen.; M. B. Sporn, A. B. Roberts, eds. - New York, NY, USA: Springer-Verlag, 1991. - P. 249-265.
17. Marchitelli, C. Milk fatty acid variability: effect of some candidate genes involved in lipid synthesis / C. Marchitelli [et al.] // Journal of dairy research. 2013. V. 80. P. 165-173. https://doi.org/10.1017/S002202991300006X
18. Zhou, H. Variation in the bovine FABP4 gene affects milk yield and milk protein content in dairy cows / H. Zhou [et al.] // Scientific reports. 2015. V. 5 (1). https://doi.org/10.1038/srep10023
19. Spitsberg, V. L. Association and coexpression of fatty-acid-binding protein and glycoprotein CD36 in the bovine mammary gland / V. L. Spitsberg, E. Matitashvili, R. C. Gorewit // European journal of biochemistry. 1995. V. 230. P. 872-878. https://doi.org/10.1111/j.1432-1033.1995.tb20630.x
20. Spitsberg, V. L. In vitro phosphorylated bovine milk fat globule membrane proteins / V. L. Spitsberg, R. C. Gorewit // The Journal of Nutritional Biochemistry. 1997. V. 8. P. 181-189. https://doi.org/10.1016/S0955-2863(97)00001-6
