The prevalence of opioid dependence among the able-bodied population is an important medical and social problem. Methylenetetrahydrofolate reductase (MTHFR) plays a key role in the metabolism of narcotic drugs. A decrease in the enzyme activity in polymorphic variants of the gene encoding it is associated with a decrease in the immunity of opioid addiction patients.
Opioids, apoptosis, lymphocyte atypical form, MTHFR
1. Naumov, A.V. Three ways of remethylation of homocysteine / A.V. Naumov, I.V. Danilchik, Yu.V. Sarana // Journal of Grodno State Medical University, 2016. 2(54), 2016. P. 27-32.
2. Pankova, E.E. Polymorphism C677T of the MTGFR gene as a risk factor for congenital pathology in descendants / E.E. Pankova, L.V. Zinchenko, S.A. Matulevich // Kuban Scientific Medical Bulletin 2009, No.6. pp. 144-147.
3. Kim, J. Causes of hyperhomocysteinemia and its pathological significance / J. Kim, H. Kim, H. Ro, Y. Kwon // Arch Pharm Res, 2018. No.41(4). pp. 372-383. doi:https://doi.org/10.1007/s12272-018-1016-4.
4. Zhao, T. Folic Acid Weakens Glia Activation in Newborn Mice and Improves Mood Disorders in Adults Through Epigenetic regulation / T. Zhao, D. Wu, J. Du, G. Liu, G. Ji, Z. Wang, F. Peng, L. Man, W. Zhou, A. Hao // Front Pharmacol, 2022. No.7. pp.13:818423. doihttps://doi.org/10.3389/fphar.2022.
5. Ganguli, P. The role of homocysteine in the development of cardiovascular diseases / P. Ganguli, S.F. Alam // Nutr J, 2015. No.10. pp.14:6. doi:https://doi.org/10.1186/1475-2891-14-6.
