PREDICTIVE AND PROGNOSTIC SIGNIFICANCE OF EXPRESSION AND ABERRATIONS OF THE DNA COPY NUMBER OF CHEMOSENSITIVITY GENES IN PATIENTS WITH BREAST CANCER
Authors:
2.
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
(Researcher)
employee
employee
Type:
Сonference abstract
Published:
16.02.2023
Subject area:
UDK 61 Медицина. Охрана здоровья. Пожарное дело
Language:
Russian
Keywords:
breast cancer, gene expression, gene aberration, neoadjuvant chemotherapy, survival
Funding:
rabota podderzhana grantom RNF 22-25-00499
Abstract (English):
Increasingly, researchers are focusing on the susceptibility of breast tumors (BC) to certain chemotherapy drugs and personalizing studies based on an assessment of this susceptibility. One such personalized approach is the assessment of chemotherapy gene expression and aberrations in the number of DNA copies — deletions and amplifications that affect gene activity. Comprehensive assessment of gene expression of chemotherapy drugs is important not only for understanding the heterogeneity and molecular biology of breast cancer, but also for obtaining a more accurate prognosis of the disease. Thus, the aim of the work is to analyze the relationship between the expression of chemosensitivity genes ERCC1, RRM1, TOP1, TOP2α, TUBB3, TYMS, GSTP1 and the effect of neoadjuvant chemotherapy (NCT).
Increasingly, researchers are focusing on the susceptibility of breast tumors (BC) to certain chemotherapy drugs and personalizing studies based on an assessment of this susceptibility. One such personalized approach is the assessment of chemotherapy gene expression and aberrations in the number of DNA copies — deletions and amplifications that affect gene activity. Comprehensive assessment of gene expression of chemotherapy drugs is important not only for understanding the heterogeneity and molecular biology of breast cancer, but also for obtaining a more accurate prognosis of the disease. Thus, the aim of the work is to analyze the relationship between the expression of chemosensitivity genes ERCC1, RRM1, TOP1, TOP2α, TUBB3, TYMS, GSTP1 and the effect of neoadjuvant chemotherapy (NCT).
Keywords:
breast cancer, gene expression, gene aberration, neoadjuvant chemotherapy, survival
breast cancer, gene expression, gene aberration, neoadjuvant chemotherapy, survival
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