THE BASIS OF MOLECULAR GENETIC CLASSIFICATION OF BREAST TUMORS WITH A TRIPLE NEGATIVE PHENOTYPE
Authors:
2.
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
(Researcher)
employee
employee
Type:
Сonference abstract
Published:
16.02.2023
Subject area:
UDK 61 Медицина. Охрана здоровья. Пожарное дело
Language:
Russian
Keywords:
trizhdy negativnyy rak molochnoy zhelezy, mutacii genov, amplifikacii genov stvolovosti, neoad'yuvantnaya himioterapiya, vyzhivaemost', prognoz
Abstract (English):
Current knowledge of the genetic heterogeneity of the most aggressive molecular subtype of breast cancer (BC) - triple negative (TN) - has led to promising discoveries in drug treatment, including the use of DNA-damaging agents (platinum drugs and PARP inhibitors) in these tumors, as well as current use of immunotherapy. Of greatest importance is the ability to prescribe optimal drug treatment regimens to patients with TN in breast cancer, based on knowledge of the molecular genetic characteristics of this subtype of breast cancer, which will ultimately allow achieving high rates of overall and relapse-free survival. Thus, the identification of the molecular genetic phenotype of breast carcinomas is an important prognostic factor of the disease and makes it possible to personalize the treatment of patients. The purpose of this work was to present a new approach to the molecular genetic classification of TN in breast cancer with predicting the outcome of patients.
Current knowledge of the genetic heterogeneity of the most aggressive molecular subtype of breast cancer (BC) - triple negative (TN) - has led to promising discoveries in drug treatment, including the use of DNA-damaging agents (platinum drugs and PARP inhibitors) in these tumors, as well as current use of immunotherapy. Of greatest importance is the ability to prescribe optimal drug treatment regimens to patients with TN in breast cancer, based on knowledge of the molecular genetic characteristics of this subtype of breast cancer, which will ultimately allow achieving high rates of overall and relapse-free survival. Thus, the identification of the molecular genetic phenotype of breast carcinomas is an important prognostic factor of the disease and makes it possible to personalize the treatment of patients. The purpose of this work was to present a new approach to the molecular genetic classification of TN in breast cancer with predicting the outcome of patients.
Keywords:
trizhdy negativnyy rak molochnoy zhelezy, mutacii genov, amplifikacii genov stvolovosti, neoad'yuvantnaya himioterapiya, vyzhivaemost', prognoz
trizhdy negativnyy rak molochnoy zhelezy, mutacii genov, amplifikacii genov stvolovosti, neoad'yuvantnaya himioterapiya, vyzhivaemost', prognoz
1. OSNOVA MOLEKULYaRNO-GENETIChESKOY KLASSIFIKACII OPUHOLI MOLOChNOY ZhELEZY S TROYNYM NEGATIVNYM FENOTIPOM
