Objective: To study and compare the associations of FTO (rs9939609), ADRB3 (rs4994) gene polymorphisms with obesity in sick and healthy Kuzbass residents. The data of 1149 people (568 control and 581 main group) were used in this work. After statistical processing of the data, it was found that rs9939609 of FTO gene increases the risk of obesity in both healthy and atherosclerosis patients. No statistically significant associations were found in the ADRB3 gene.
obesity, genes, polymorphism, FTO, ADRB3
1. Dedov, I.I. Obesity / I.I. Dedov [et al] // Consilium Medicum. 2021. No 23. pp. 311-325.
2. Alfyorova V.I., Mustafina S.V. Obesity prevalence in the adult population of the Russian Federation (review of literature) / V.I. Alfyorova, S.V. Mustafina // Obesity and metabolism. 2022. No 1. pp. 96-105.
3. metabolism and obesity: contribution of leptin receptor gene / K.D. Ievleva [et al.] // Acta Biomedica Scientifica. 2017. Vol. 2., No. 5. pp. 56-62.
4. Chauhdary, Z. The composite alliance of FTO locus with obesity-related genetic variants / Z. Chauhdary, K. Rehman, M.S.H. Akash // Clin Exp Pharmacol Physiol. 2021. No 48. pp. 954-965.
5. Xie, C. The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia's population: an evidence-based meta-analysis / C. Xie [et al.] // Adipocyte. 2020. No 9. pp. 77-86.
6. Baturin A.K. Regional peculiarities of polymorphism of genes associated with obesity (rs9939609 of FTO gene and Trp64Arg of ADRB3 gene) in Russian population / A.K. Baturin [et al.] // Nutrition issues. 2014. No 83. pp.35-41.
7. Merra, G FTO rs9939609 influence on adipose tissue localization in the Italian population / G Merra [et al.] // Eur Rev Med Pharmacol Sci. 2020. No 24. pp. 3223-3235.
